The Familiar of Zero (anime)

Three Seasons. First season was good. Second season was sort of flat. Third season was a behind the lines spy drama.

Zero No Tsukaima Season 2006
Louise is in a school for magic. She uses magic to get her a familiar which is usually an animal or a thing. She gets Saito human. Coming there he gets a set of runes on the back of his hand that will let him use any practical weapon (i.e. normal swords and guns, not play/practice weapons). This mostly setup with Louise and Saito with a school setting.

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